More than shame based on their nakedness, Adam and Eve were humiliated for having blatantly disregarded God's command. The Bible says their eyes were opened, but the so-called enlightenment that the serpent had promised was sickening. Like every sensational lie of the enemy, it was nothing like what was advertised, and it was not only extremely disappointing, but vile. They felt dirty and violated. Immediately, they hurried to cover themselves.
When Adam and Eve heard the Lord God walking in the garden, they tried to hide themselves from His presence. When the Lord asked where Adam was, he admitted that he was afraid. (Genesis 3:8-10) Their eyes had been opened, but what they now saw was frightening. They had been told they would be like God, knowing good and evil. They thought they were missing out, that God was keeping something from them. He was, but it was for their protection. Now they were afraid of the One who had been perfectly trustworthy and good to them, and they felt horrible.
After God pronounced judgments on them, to replace their leaves, God made them clothes of animal skins. Although obscured, God had to sacrifice animals to get the skins, and this was temporary atoning blood. Whatever lifestyle Adam and Eve lived outside of the garden is unknown. Logically, it must have been very grievous to be ostracized, and then to labor with difficulty, both in agriculture and childbearing. To add to their sorrow, their firstborn murdered his brother, Abel, and then left the area, likely never again to be seen by Adam and Eve. The Bible does state that they gave birth to Seth, and many other sons and daughters, unnamed. Adam lived to be 930 years old according to Genesis 5:5. Except for the information about their progeny, there are no words or actions of Adam and Eve recorded.
Adam and Eve failed to have foresight, which is the downfall of many people even today. They didn't see the big picture and were apparently oblivious regarding all that was at stake. Had they obeyed, God would have provided all the knowledge they ever needed, when they needed it. Instead, their lapse of focused allegiance to God cost them everything, and brought sin and death into the world. Thankfully, God had a plan to restore to mankind all Adam lost through the righteous sacrifice of the Second Adam, Jesus Christ.